Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 325-331, 2008.
Article
in English
| WPRIM
| ID: wpr-359977
ABSTRACT
<p><b>AIM</b>To evaluate the best individualized prostate biopsy strategies for Chinese patients with suspected prostate cancer.</p><p><b>METHODS</b>The present study included 221 Chinese patients who underwent transrectal ultrasound guided prostate biopsies for the first time. All patients underwent the same 10-core biopsy protocol. In addition to the Hodge sextant technique, four more biopsies were obtained from the base and middle regions of bilateral peripheral zones. The differences between 10-core and sextant strategies in cancer detection among patients with different prostate specific antigen (PSA) levels were evaluated. The relationship between PSA level, number of positive biopsy cores and organ-confined cancer rate in prostate cancer patients was also analyzed.</p><p><b>RESULTS</b>The overall prostate cancer detection rate was 40.7% in the 221 patients. The 10-core strategy increased cancer detection by 6.67% (6/90) in our patients (P < 0.05). The increased cancer detection rates decreased significantly when the patient PSA level increased from 0-20 ng/mL to 20.1-50 ng/mL and > 50 ng/mL (P < 0.01). The number of positive biopsy cores in prostate cancer patients increased significantly with increasing patient PSA level (P < 0.01). The rate of organ-confined prostate cancer decreased significantly with increasing patient PSA level (P < 0.01).</p><p><b>CONCLUSION</b>The extended 10-core strategy is recommended for Chinese patients with PSA = or < 20 ng/mL and the sextant strategy is recommended for those with PSA > 50 ng/mL. For patients with PSA ranging from 20.1 ng/mL to 50 ng/mL, the 10-core strategy should be applied in patients with life expectancy = or > 10 years and the sextant strategy should be applied in those with life expectancy < 10 years.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostate
/
Prostatic Neoplasms
/
Biopsy, Needle
/
Blood
/
China
/
Prostate-Specific Antigen
Limits:
Aged
/
Aged80
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
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