Evidence that chronic hypoxia causes reversible impairment on male fertility / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 602-606, 2008.
Article
in English
| WPRIM
| ID: wpr-359980
ABSTRACT
<p><b>AIM</b>To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time.</p><p><b>METHODS</b>Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude (ranging from 2 000 m to 5 600 m, Karakorum Expedition) the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months.</p><p><b>RESULTS</b>Sperm count was found to be lower immediately after returning to sea level (P = 0.0004) and again after a month (P = 0.0008). Normal levels were reached after 6 months. Spermatic motility (%) shows no reduction immediately after returning to sea level (P = 0.0583), whereas after 1 month this reduction was significant (P = 0.0066). After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa (%) increased immediately after returning to sea level (P = 0.0067) and then again after 1 month (P = 0.0004). After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level (P = 0.0024) and then again after 1 month (P = 0.0021). After 6 months there was a recovery to pre-hypoxic exposure values.</p><p><b>CONCLUSION</b>Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Pathology
/
Physiology
/
Sperm Count
/
Sperm Motility
/
Spermatogenesis
/
Adaptation, Physiological
/
Altitude
/
Infertility, Male
/
Hypoxia
Type of study:
Etiology study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
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