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Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study / 亚洲男科学杂志(英文版)
Asian Journal of Andrology ; (6): 651-658, 2008.
Article in English | WPRIM | ID: wpr-359988
ABSTRACT
<p><b>AIM</b>To conduct a double-blind, placebo-controlled randomized and dose-ranging study to evaluate the safety and efficacy of the extract of Ganoderma lucidum (G. lucidum) in men with lower urinary tract symptoms (LUTS).</p><p><b>METHODS</b>We enrolled male volunteers (> or = 50 years) with an International Prostate Symptom Score (IPSS; questions 1-7) > or = 5 and a prostate-specific antigen (PSA) value < 4 ng/mL. Volunteers were randomized into groups of placebo (n = 12), G. lucidum of 0.6 mg (n = 12), 6 mg (n = 12) or 60 mg (n = 14), administered once daily. Efficacy was measured as a change from baseline in IPSS and the peak urine flow rate (Q(max)). Prostate volume and residual urine were estimated by ultrasonography, and blood tests, including PSA levels, were measured at baseline and at the end of the treatment.</p><p><b>RESULTS</b>The overall administration was well tolerated, with no major adverse effects. Statistical significances in the magnitude of changes between the experimental groups were observed at weeks 4 and 8. No changes were observed with respect to Q(max), residual urine, prostate volume or PSA levels.</p><p><b>CONCLUSION</b>The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostate / Prostatic Hyperplasia / Urinary Incontinence / Blood / Drugs, Chinese Herbal / Pilot Projects / Double-Blind Method / Treatment Outcome / Prostate-Specific Antigen Type of study: Controlled clinical trial / Diagnostic study Limits: Aged / Humans / Male Language: English Journal: Asian Journal of Andrology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostate / Prostatic Hyperplasia / Urinary Incontinence / Blood / Drugs, Chinese Herbal / Pilot Projects / Double-Blind Method / Treatment Outcome / Prostate-Specific Antigen Type of study: Controlled clinical trial / Diagnostic study Limits: Aged / Humans / Male Language: English Journal: Asian Journal of Andrology Year: 2008 Type: Article