Research Advances of A New Co-stimulatory Molecule-B7 Homolog 6--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 295-298, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-360098
ABSTRACT
B7-H6 is a co-stimulatory molecule discoveried recently. B7-H6 is not expressed on normal cells, but specially expressed on tumor cells. It can also be expressed on antigen presenting cells (APC) by the induction. The B7-H6 expression can be downregulated by HDACi. NK cells can be activated to release TNFα and IFNγ through B7H6-NKp30 pathway. The B7-H6 molecules expressed on the cell surface can be shedded to form soluble molecules. In the meantime, the B7-H6/NKp30 pathway may be involved in the pathogenesis of primary Sjogren syndrome. B7-H6/NKp30 may become a new therapeutic target for tumor, inflammation and autoimmune diseases. This review discusses the B7-H6 and receptor sructure, the expression and significance of B7-H6, the function and regulating mechanism of B7-H6 and the soluble molecules of B7-H6.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Killer Cells, Natural
/
Down-Regulation
/
Natural Cytotoxicity Triggering Receptor 3
/
B7 Antigens
/
Inflammation
/
Metabolism
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2016
Type:
Article
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