Research Progress on Drug-resistance of Acute Lymphoblastic Leukemia--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 261-265, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-360105
ABSTRACT
Acute lymphoblastic leukemia (ALL) is a malignant clonal disease, its treatment methods include chemotherapy, hematopoietic stem cell transplantation, immunotherapy and molecular targeted therapy. Clinically, ALL patients need to get complete remission through chemotherapy, and then choose the other treatment according to the patient's condition. But the drug resistance has been a biggest obstacle in treatment of ALL. There are many research reports about drug-resistant of ALL at present. In this review, the classic drug resistance mechanisms, such as membrane transporter, gene modifications and some newly finding mechanisms including such as bone marrow microenvironment and Micro RNA and so on are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Physiology
/
Bone Marrow
/
Drug Resistance, Neoplasm
/
MicroRNAs
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Cellular Microenvironment
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2016
Type:
Article
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