Intervening effect of naoxintong on anti-platelet treatment with aspirin / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 843-846, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-360543
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of small dosage aspirin on platelet biochemical indexes in patients with cardio-cerebrovascular diseases and the intervening action of Naoxintong (NXT).</p><p><b>METHODS</b>The blood levels of P-selectin (P), thrombin B2 (TXB2), and platelet aggregation (PAG) induced by arachidonic acid (AA) and adenosine diphosphate (ADP) were determined in 145 patients with cardio-cerebrovascular diseases (diabetes mellitus, hypertension, coronary heart disease and cerebral infarction), after they were medicated with aspirin 100 mg per day for 7 days. Then they were randomly assigned to the aspirin group and the NXT group Both groups took aspirin 100 mg per day continually, but to patients in the NXT group, NXT 9 tablets per day was given additionally. The blood levels of above-mentioned biochemical indexes were re-examined 1 month after medication.</p><p><b>RESULTS</b>The first determination showed the plasma level of P-selectin and TXB2 concentration were positively correlated with PAG, either induced by AA (r = 0.449, P < 0.01 and r = 0.576, P < 0.01) or by ADP (r = 0.525, P < 0.01; r = 0.501, P < 0.01). Positive correlation also showed between plasma level of P-selectin and TXB2 (r = 0.610, P < 0.01). There was no significant difference of all the three indexes between the two groups (P > 0.05). Re-examination showed that levels of the 3 indexes significantly decreased in both groups (P < 0.01), and all were lower in the NXT group than in the aspirin group respectively (P < 0.05). There was no significant difference in the incidence of adverse reaction between two groups (P > 0.05).</p><p><b>CONCLUSION</b>The anti-platelet effect of one-week administration of aspirin for patients with cardio-cerebrovascular diseases can not be optimal, the combination with NXT could enhance the effect without increase of adverse reaction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Blood
/
Blood Platelets
/
Drugs, Chinese Herbal
/
Platelet Aggregation Inhibitors
/
Platelet Aggregation
/
Aspirin
/
P-Selectin
/
Coronary Disease
/
Drug Therapy
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2008
Type:
Article
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