Protective effect of compound tongfu granule on intestinal mucosal barrier in patients with cirrhosis of decompensation stage / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 784-787, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-360557
ABSTRACT
<p><b>OBJECTIVE</b>To explore the intestinal mucosal barrier protective effect of herbal medicine Compound Tongfu Granule (CTG) in patients with liver cirrhosis of decompensation stage.</p><p><b>METHODS</b>Fifty patients enrolled were randomly assigned to the control group (26 cases) and the CTG group (24 cases), and 30 healthy adults were set up as normal control. After 2-week treatment, the intestinal permeability (IP, represented by urinary lactulose/mannitol excretion rate), plasma endotoxin (EDT) level, and change of enteric bacteria (EB) in patients were observed before and after treatment, and compared with those in the normal control.</p><p><b>RESULTS</b>Before treatment, cirrhotic patients showed significantly higher levels of IP, EDT, and intestinal bacilli, but a lower amount of enteric bifidobacteria as compared with those the normal control. After 2-week treatment, levels of EDT and urinary excretion rate of lactulose in the CTG group were lowered more significantly than those in the control group (P < 0.05), while the amount of bifidobacteria in the CTG group increased accompanied with intestinal bacilli significantly lowered to near the levels in the normal control (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>CTG can improve the intestinal barrier function, correct the intestinal bacteria disturbance, and significantly reduce the entero-derived endotoxemia in cirrhotic patients of decompensation stage.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bifidobacterium
/
Drugs, Chinese Herbal
/
Cell Membrane Permeability
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
/
Endotoxins
/
Intestinal Mucosa
/
Lactulose
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2008
Type:
Article
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