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Perilipin gene 1237 T > C polymorphism is not associated with obesity risk in northern Chinese Han adults / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 442-447, 2009.
Article in English | WPRIM | ID: wpr-360642
ABSTRACT
<p><b>OBJECTIVE</b>To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults.</p><p><b>METHODS</b>A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression.</p><p><b>RESULTS</b>The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P = 0.4) and 0.6 (0.3, 1.3) in men (P = 0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity.</p><p><b>CONCLUSION</b>Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T > C polymorphism is not significantly associated with obesity in northern Chinese adults.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphoproteins / Carrier Proteins / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Perilipin-1 / Genetics / Metabolism / Obesity Type of study: Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Biomedical and Environmental Sciences Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphoproteins / Carrier Proteins / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Perilipin-1 / Genetics / Metabolism / Obesity Type of study: Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Biomedical and Environmental Sciences Year: 2009 Type: Article