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Expression of matrix metalloproteinase-2 and insulin-like growth factor-1 in gastric carcinoma and their clinicopathological significance / 中华外科杂志
Chinese Journal of Surgery ; (12): 774-779, 2010.
Article in Chinese | WPRIM | ID: wpr-360773
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of matrix metalloproteinase-2 (MMP-2) and insulin-like growth factor-1 (IGF-1) in gastric carcinoma and their clinicopathological significance.</p><p><b>METHODS</b>Expressions of MMP-2 and IGF-1 were examined by using immunohistochemical SP staining and cross-compared with clinicopathological features of gastric carcinoma.</p><p><b>RESULTS</b>High expression of MMP-2 and IGF-1 were observed in 70.4% (307/436) and 49.5% (216/436) of gastric carcinoma tissues respectively, significantly higher than those in non-tumor gastric mucosa (3.3% and 5.4%, respectively; all P < 0.05). The high expression rate of MMP-2 and IGF-1 were significantly associated with the patient age, tumor size, tumor location, Lauren classification, TNM staging, depth of tumor infiltration, presence of vessel invasion, lymph node and distant metastasis (all P < 0.05). In addition, the expression of MMP-2 was positively linked with the expression level of IGF-1 (P < 0.05). Univariate analysis showed that high expression of MMP-2, was significantly associated with poor prognosis of tumor of TNM stage I and II (all P < 0.05), high expression of IGF-1 was significantly correlated with poor prognosis of patients with TNM stage I, II and III tumor (all P < 0.05). Cox multivariate analysis indicated that the high expressions of MMP-2 and IGF-1 could be independent prognostic indices for gastric carcinoma.</p><p><b>CONCLUSIONS</b>High expression of MMP-2 and IGF-1 proteins are significantly correlated with the invasion and metastasis of gastric carcinoma, it is helpful to simultaneously detect the expressions of MMP-2 and IGF-1 proteins in predicting prognosis of patients with gastric carcinoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Stomach Neoplasms / Insulin-Like Growth Factor I / Matrix Metalloproteinase 2 / Lymphatic Metastasis / Metabolism / Neoplasm Invasiveness Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Stomach Neoplasms / Insulin-Like Growth Factor I / Matrix Metalloproteinase 2 / Lymphatic Metastasis / Metabolism / Neoplasm Invasiveness Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2010 Type: Article