Study on the potentiation of bone marrow mesenchymal stem cells involved in sebaceous duct formation / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the feasibility of differentiation of bone marrow mesenchymal stem cells (MSCs) into skin appandence.</p><p><b>METHODS</b>Porcine MSCs were isolated from porcine marrow and grown in vitro. After labeling with BrdU, MSCs were engrafted to porcine skin. At 1, 2, 4 weeks after the transplantation, immunohistochemical examinations were carried out to detect the positive staining of BrdU and cytokeratin.</p><p><b>RESULTS</b>A few sebaceous duct cells, which expressed cytokeratin, were also BrdU positive, and these cells were considered may to be transplanted MSCs-derived cells.</p><p><b>CONCLUSION</b>Porcine MSCs might have the potential to differentiated into sebaceous duct cells in skin.</p>