Experiment of rhBMP-2 in posterolateral spinal fusion in aged rabbits / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 28-32, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-360998
ABSTRACT
<p><b>OBJECTIVE</b>Posterolateral intertransverse process fusion was performed in aged and young adult female rabbits lumbar spine using recombinant human bone morphogenetic protein-2 (rhBMP-2) and autograft to reveal the function of rhBMP-2 on spinal fusion on aged animals.</p><p><b>METHODS</b>A total of 24 female New Zealand white rabbits included 12 young adult of 6 months and 12 aged of 2-year-old, was divided into 4 groups (1) young adult autologous iliac crest bone group [ICBG(Y), n=6); (2) young adult rhBMP-2/absorbable collagen sponge (ACS) group [BMP-2(Y), n=6]; (3) aged autologous iliac crest bone group [ICBG(O), n=6]; aged rhBMP-2/ACS group [BMP-2(O), n=6]. All were underwent posterolateral fusion in same day. rhBMP-2 and autologous iliac crest bone was implant bilateral LS-L6 intertransverse processes, respectively. Half of the rabbits were sacrificed at 3.6 weeks following surgery, respectively. The results were assessed by manual palpation, radiographs, computed tomographic scans (3D) and histology.</p><p><b>RESULTS</b>Six weeks after surgery, radiography, computed tomography and histology indicated the different result in healing in the posterolateral fusion using rhBMP-2 compared to ICBG (P < 0.05). Aged BMP-2 group showed significantly higher fusion rates than Aged ICBG group.</p><p><b>CONCLUSION</b>This study demonstrated rhBMP-2 can increase the posterolateral fusion rate and new bone quality in aged rabbitss than autograft, it may take the place of ICBG. But its role is effected by age.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Palpation
/
Pathology
/
Pharmacology
/
Spinal Cord
/
Spinal Fusion
/
General Surgery
/
Transplantation
/
Transplantation, Autologous
/
Recombinant Proteins
/
Aging
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS