A Case of Antithrombin III Deficiency Diagnosed and Treated During Mitral Valve Replacement / Journal of Rural Medicine
Journal of Rural Medicine
;
: 23-24, 2007.
Article
in Japanese
| WPRIM
| ID: wpr-361323
ABSTRACT
Objective:
To asses the risk of acquired antithrombin III (AT III) deficit before heart surgery and consider countermeasures. Patient A 50-year-old gentleman who suffered from congestive heart failure due to mitral valve regurgitation.Methods:
We replaced the mitral valve with cardiopulmonary bypass. Activated clotting time (ACT) was not long enough even after general heparinization (300 U/Kg) for cardiopulmonary bypass. We measured the activity of antithrombin III and added a total 50000 units of heparin until ACT was over 400 sec. We noted low AT III activity (36.8%) and transfused 4 U of fresh frozen plasma (FFP) during surgery.Results:
After administration of protamine (0.3 ml/Kg), ACT reached 137 sec. The hemostasis procedure was uneventful and the patient recovered well without a bleeding incident.Conclusion:
Measurement of AT III activity just before the initiation of cardiopulmonary bypass is necessary to avoid insufficient anticoagulation such as antithrombin III deficit.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cardiopulmonary Bypass
/
Antithrombin III
/
Mitral Valve
Type of study:
Diagnostic study
Language:
Japanese
Journal:
Journal of Rural Medicine
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS