Negative Results of \it{umu} Genotoxicity Test of Fluorotelomer Alcohols and Perfluorinated Alkyl Acids
Environmental Health and Preventive Medicine
;
: 217-219, 2007.
Article
in Japanese
| WPRIM
| ID: wpr-361342
ABSTRACT
Objectives:
Recently, perfluorooctanoate (PFOA) has been ubiquitously detected in the environment as well as in human serum. Fluorotelomer alcohols (FTOHs), a precursor of PFOA, undergo biodegradation via several metabolic routes which leads to formation of various biodegradation products. The degradation of FTOHs produces an α,β-unsaturated aldehyde that seems possibly to be electrophilic and may react with cellular macromolecules including DNA.Methods:
We investigated the genotoxicity of three FTOHs (62 FTOH, 82 FTOH and 102 FTOH), PFOA and perfluorooctane sulfonate (PFOS) using the umu test.Results:
The FTOHs, PFOA and PFOS showed no significant increases in β-galactosidase activity at 0−1000 μM in the absence of S9 mix. The results were unchanged by the metabolic activation with S9 mix.Conclusion:
The genotoxicities of FTOHs, PFOA or PFOS are not detectable using the present method, suggesting that they are unlikely mutagens.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acids
/
Alcohols
/
Mutagenicity Tests
Language:
Japanese
Journal:
Environmental Health and Preventive Medicine
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS