Detection of Anti-Topoisomerase I Autoantibody in Patients with Silicosis
Environmental Health and Preventive Medicine
;
: 7-10, 2002.
Article
in Japanese
| WPRIM
| ID: wpr-361495
ABSTRACT
Objectives:
The aim of this study was to detect anti-topoisomerase l (anti-topo I) autoantibodies, which are known to be limited in systemic sclerosis patients, in silicosis patients with no clinical symptoms of autoimmune disease.Methods:
Serum anti-topo I autoantibodies were detected using ELISA. Differences in clinical parameters between patients with and without anti-topo I autoantibodies were analyzed.Results:
Seven of 69 patients had anti-topo I autoantibodies. These 7 patients showed elevated PaCO2 values (P=0.0212), and inverse correlations between serum soluble Fas levels and PaCO2 values were found.Conclusion:
Anti-topo I autoantibodies were detected in 10.1% of silicosis patients without any clinical symptoms of autoimmune disease. The findings here suggest that the genesis of anti-topo l autoantibodies might be related to pulmonary involvement or lung fibrosis associated with progression of silicosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Silicosis
/
Autoantibodies
Type of study:
Diagnostic study
Language:
Japanese
Journal:
Environmental Health and Preventive Medicine
Year:
2002
Type:
Article
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