Concurrent response to challenge infection with Cryptosporidium parvum in immunosuppressed C57BL/6N mice
Journal of Veterinary Science
;
: 47-51, 2006.
Article
in English
| WPRIM
| ID: wpr-36289
ABSTRACT
We investigated the response to challenge infection with Cryptosporidium parvum oocysts in immunosuppressed C57BL/6N mice. In the primary infection, fecal oocyst shedding and parasite colonization were greater in immunosuppressed mice than in nonimmunosuppressed mice. Compared with primary infection, challenge infection with C. parvum didn't show any oocyst shedding and parasite colonization. Especially, oocyst shedding and parasite colonization from the mice infected with heatkilled oocysts were not detected. After challenge infection with C. parvum oocysts, however, these mice were shedding small numbers of oocysts and parasite colonization. Except normal control and uninfected groups, the antibody titers of other groups appear similar. Based on the fecal oocyst shedding, parasite colonization of ilea, and antibody titers in the mice, these results suggest that the resistance to challenge infection with C. parvum in immunosuppressed C57BL/6N mice has increased.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dexamethasone
/
Enzyme-Linked Immunosorbent Assay
/
Antibodies, Protozoan
/
Random Allocation
/
Immunocompromised Host
/
Cryptosporidium parvum
/
Fluorescent Antibody Technique, Indirect
/
Cryptosporidiosis
/
Oocysts
/
Feces
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2006
Type:
Article
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