A Rare Manifestation of Hypothyroid Myopathy: Hoffmann's Syndrome
Endocrinology and Metabolism
;
: 626-630, 2015.
Article
in English
| WPRIM
| ID: wpr-36340
ABSTRACT
Hypothyroid myopathy is observed frequently and the resolution of the clinical manifestations of myopathy following thyroid hormone replacement is well known. However, a specific subtype of hypothyroid myopathy, Hoffmann's syndrome, characterized by increased muscular mass (pseudohypertrophy), proximal muscle weakness, muscle stiffness and cramps, is rarely reported. Herein, we describe a 34-year-old male who presented with proximal muscle weakness and non-pitting edema of the lower extremities. He initially visited the neurology department where he was suspected of having polymyositis. Additional laboratory evaluation revealed profound autoimmune hypothyroidism and elevated muscle enzymes including creatine kinase. The patient was started on levothyroxine treatment and, subsequently, clinical symptoms and biochemical parameters resolved with the treatment. The present case highlights that hypothyroidism should be considered in the differential diagnosis of musculoskeletal symptoms even in the absence of overt manifestations of hypothyroidism. To our knowledge, this is the first case reported in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Gland
/
Thyroxine
/
Polymyositis
/
Muscle Weakness
/
Creatine Kinase
/
Lower Extremity
/
Diagnosis, Differential
/
Edema
/
Hypothyroidism
/
Korea
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS