Chorionic Villus Sampling: Clinical and Cytogenetic Study of the First 1,058 Cases in YUMC from 1984 to 2004 years / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1654-1662, 2005.
Article
in Korean
| WPRIM
| ID: wpr-36513
ABSTRACT
OBJECTIVE:
This study was performed to evaluate the feasibility, accuracy and safety of Chorionic Villus Sampling (CVS).METHODS:
We analyzed the outcome of 1,058 cases of CVS performed for prenatal genetic diagnosis between 7 and 12 weeks of gestation in the outpatient prenatal genetic clinic in Yonsei University Medical Center (1,030 cases by trans-cervical method and 28 cases by trans-abdominal). Fetal Karyotyping was obtained by direct or indirect culture methods using Gimsa and Gimsa-Banding.RESULTS:
Advanced maternal age was the most common indication for CVS (34.7%). The overall sampling success rate was 98% (1040/ 1,058), representing 92.5% in 7 to 8 weeks, 98.0% in 9 to 10 weeks, and 98.9% in 11 to 12weeks of gestation. The majority of cases (94.6%) required one or two aspirations. Cytogenetic analysis routinely included direct overnight and long-term culture methods, which revealed 27 chromosomal abnormalities (2.6%). Of 1,040 cases in which CVS were successful, 989 delivered normal baby, 23 resulted in fetal loss, 25 had therapeutic termination (24 with chromosome abnormalities and 1 with normal chromosome with huge myoma), and 3 with chromosome abnormalities were loss to follow up. The overall fetal loss rate was 2.2% (23/1,058). No congenital anomalies were found to be related to CVS in these series.CONCLUSION:
When performed by experienced operators and cytogeneticists beyond 9 weeks of gestation, CVS is a feasible, accurate and safe method for prenatal genetic diagnosis capable of replacing genetic amniocentesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Aspirations, Psychological
/
Chorionic Villi Sampling
/
Follow-Up Studies
/
Chorion
/
Chorionic Villi
/
Chromosome Aberrations
/
Maternal Age
/
Cytogenetic Analysis
/
Cytogenetics
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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