Experimental Study on Combined Driving by Synchronized Coronary Sinus Retro-perfusion (SCSR) and Intra-aortic Balloon Pumping (IABP) to Support Coronary Circulation / 日本心臓血管外科学会雑誌

ABSTRACT

In order to support coronary circulation for the ischemic myocardium, the effect of simultaneous driving by means of SCSR and IABP was experimentally studied in 28 pigs. A myocardial infarction model was prepared by ligating branches of left anterior descending (LAD). All the animals were divided into four groups controls, IABP-, SCSR-, and SCSR with IABP-assisted. The results were evaluated as to chronological hemodynamic changes, infarct areas as depicted by epicardial mapping electrocardiograms, myocardial regional blood flow, and morphological changes. All the groups with assist devices showed improved hemodynamic features compared with the control group. The SCSR+IABP group achieved the best recovery from infarction among the groups. A remarkable improvement of ischemic change in the area bordering the infarct was confirmed morphologically. In conclusion it is suggested that simultaneous driving of SCSR and IABP provides an effective auxiliary circulation for serious cases of ischemic heart disease in which antegrade coronary flow is reduced significantly.