Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Production in Mice
Journal of Veterinary Science
;
: 103-108, 2003.
Article
in English
| WPRIM
| ID: wpr-36633
ABSTRACT
The dietary effect of conjugated linoleic acid (CLA) on the response of the immunoglobulin (serum and tissue) production in Balb/C mice was examined at three doses 0 %(control), 0.5% and 1.5%. The combination effects of CLA with vitamin ADE or selenium also were investigated. CLA at 0.5% increased serum immunoglobulin A, G, mesenteric lymp node (MHN) and gut luminal IgA (secretory IgA) levels. However, 1.5% CLA decreased SIgG slightly. CLA both alone and combined with vitamin ADE and selenium did not affect serum IgE. The levels of immunoglobulin concentration in the 0.5% CLA group were higher than those in the1.5% CLA group. The level of serum IgG in 1.5% CLA combined with selenium was maintained at the same level as that of control. It is considered that over- doses of CLA (1.5%) even depressed the production of immunoglobulin but selenium and/or vitamin inhibited this activity to a certain extent.In this study, dietary CLA increased immunoglobulin production in a dose-dependent manner. Vitamin ADE and Selenium combined with CLA also increased the immunoglobulin production response except serum IgE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Selenium
/
Vitamin A
/
Immunoglobulins
/
Linoleic Acid
/
Dose-Response Relationship, Drug
/
Drug Therapy, Combination
/
Intestines
/
Lymph Nodes
/
Mice, Inbred BALB C
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2003
Type:
Article
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