Differential Expression of E-Cadherin, beta-Catenin, and S100A4 in Intestinal Type and Nonintestinal Type Ampulla of Vater Cancers
Gut and Liver
;
: 94-101, 2014.
Article
in English
| WPRIM
| ID: wpr-36647
ABSTRACT
BACKGROUND/AIMS:
Epithelial-mesenchymal transition (EMT)-related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs). We evaluated the expression of E-cadherin, beta-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival.METHODS:
A clinicopathological review of 105 patients with AVCs and immunohistochemical staining for E-cadherin, beta-catenin, and S100A4 were performed. The association between clinicopathological parameters, histological type, and expression of EMT proteins and their effects on survival were analyzed.RESULTS:
Sixty-five intestinal type, 35 pancreatobiliary type, and five other types of AVCs were identified. The severity of EMT changes differed between the AVC types; membranous loss of E-cadherin and beta-catenin was observed in nonintestinal type tumors, whereas aberrant nonmembranous beta-catenin expression was observed in intestinal type tumors. EMT-related changes were more pronounced in the invasive tumor margin than in the tumor center, and these EMT-related changes were related to tumor aggressiveness. Among the clinicopathological parameters, a desmoplastic reaction was related to overall survival, and the reaction was more severe in nonintestinal type than in intestinal type AVCs.CONCLUSIONS:
Dysregulation of E-cadherin, beta-cadherin, and S100A4 expression may play a role in the carcinogenesis and tumor progression of AVCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Ampulla of Vater
/
S100 Proteins
/
Biomarkers, Tumor
/
Cadherins
/
Retrospective Studies
/
Common Bile Duct Neoplasms
/
Disease-Free Survival
/
Beta Catenin
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS