Circumstances surrounding the Completion of Kampo Formula, Kakkon-to-ka-senkyu-shin'i / 日本東洋医学雑誌

ABSTRACT

It has hitherto been believed that Kakkon-to plus Senkyu-shin'i was invented by Japanese. In his article entitled “On the Development of the Kampo formula, Kakkon-to-ka-Senkyu-shin'i”, Terasawa wrote that there is no literature available up to 1940's which specified the addition of Shin'i and that there is no definite data concerning the source of Shin'i. I studied the addition of Senkyu and Shin'i taking the above into consideration. I discovered how Magnolia kobus had been replaced by Shin'i, that it is described in “Ben cao gang mu”, and that there were schools, such as Yoshimasu Todo's which never prescribed Shin'i. I also found that Kakkon-to combined with other herbs was used in the treatment of syphilis in the Edo era, and that there are combinations containing Senkyu, Shin'i, or Senkyu plus Shin'i, which were used according to the status of syphilid and to reduce adverse reactions of mercurial agents. In my present investigation, the closest formulation to Kakkon-to plus Senkyu-shin'i is Kakkon-to-combined-gomotsu-gedoku-to plus Shin'i.