Clinical Evaluation of the Chinese Herbal Extracts(Sho-Seiryu-to) in Treatment of Bronchial Asthma. Results of a Multicenter Clinical Study Based on Evaluation Methods for Western Drugs / 日本東洋医学雑誌

ABSTRACT

The authors investigated the efficacy, safety and usefulness of the Kampo extract Shoseiryu-to (TJ-19) in the treatment of adult bronchial asthma. The multi-center study used the same methods presently in use in Japan for clinical evaluation of Western drugs and included a total of 69 patients in an open trial.<br>After long-term (4-8 weeks) administration of the Kampo formula in conjunction with conventional bronchial dilators, a significant improvement was seen in the frequency score, clinical score and asthma score. Significant improvement was observed in individual symptoms such as phlegm viscosity and amount, daily life, sleep, sneezing and nasal discharge. Overall, the results indicated marked improvement in 13 patients (18.8%), moderate improvement in 23 patients (33.3%) and slight improvement in 19 patients (27.5%). Thus, the authors obtained the favorable results of moderate or better improvement in 52.2% and slight or better improvement in 79.9% of the patients. We observed almost no abnormal findings in laboratory examinations due to the drugs. Side effects developed only in a few patients in the form of a slight cough. Symptoms of nasal allergy improved most frequently according to the impressions of the physicians in charge. Recently, combination therapy using various Kampo extracts has increased in Japan in order to improve treatment quality.