Effect of Kyuki-kyogai-to on Stopping Dysfunctional Uterine Bleeding. Comparison with Occidental Hematostatic Drug / 日本東洋医学雑誌

ABSTRACT

We investigated the number of days necessary to stop bleeding in a total of 183 cases of dysfunctional uterine bleeding in mature women (average age 41.3+/-7.2). We compared 93 cases given Kyuki-kyogai-to extract with 90 cases given the occidental hematostatic drug, Transamin (tranexamic acid in tablet form) plus Ophthalm K tablets (carbazochrom+VitaminK+Vitamin C) for 7 days from the first day of medical examination until the diagnosis of endometrium was determined by histologic examination. The total number of days required for the bleeding to stop showed a mean of 4.29+/-1.54 days in the Kyuki-kyogai-to administration group and 5.54+/-2.13 days in Transamin and others group. The bleeding was stopped significantly faster in the Kyuki-kyogai-to group than in the Transamin group (P<0.01 to χ² calibration [chi-square test]). The effective rates were 94.6% and 72.2% respectively. Considering the Kyojitsusho (condition of excess or deficiency), this was significant in Kyosho (condition of deficiency) and Kyojitsu-kansho (condition of between deficiency and excess), but not significant in Jitsusho (condition of excess). In terms of histological findings of endometrium, this was significant in the proliferation stage and in simple hyperplasia, but not significant in the stillness stage with an atrophic pattern, the stage of intermingled proliferation and secretion, or the secretion stage. The action mechanism of bleeding cessation remains unclear. However, it seems that Kyuki-kyogai-to is an effective herbal medicine to stop bleeding in dysfunctional uterine.