Study on preparation of indomethacin pellets with released action by push back method of forming spheroids
Pharmaceutical Journal
;
: 16-20, 2005.
Article
in Vietnamese
| WPRIM
| ID: wpr-3696
ABSTRACT
Optimum formula of indomethacin sustained release pellets prepared by extrusion and spheronization method was obtained by using an artificial neural network. In the pellets, Avicel PH 101 was used as a matrix excipient for sustained release and HPMC E15, PVP K30, polysorbat 80 was used to enhance the solubility of indomethacin from the matrix. The capsules containing prepared indomethacin sustained release pellets showed an in vitro drug release similar to that of CHRONO-INDOCID capsules which were used as a reference product. The studied products were stable during 6 months when preserving in urgent aged condition
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmaceutical Preparations
/
Indomethacin
Language:
Vietnamese
Journal:
Pharmaceutical Journal
Year:
2005
Type:
Article
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