A Study on the Incidence and Risk factors of Cystic Periventricular Leukomalacia in very Low Birth Weight Infants
Journal of the Korean Society of Neonatology
;
: 61-66, 2003.
Article
in Korean
| WPRIM
| ID: wpr-37207
ABSTRACT
PURPOSE:
Our study was carried out to estimate the incidence of cystic periventricular leukomalacia (CPVL) and to identify the risk factors for CPVL.METHODS:
The medical records and cranial ultrasound scan were reviewed for 321 infants weighing less than 1, 500 g who lived more than 28 days and admitted to the NICU at Samsung Medical Center from October 1995 to December 2001. A multiple logistic regression was performed to identify which factors were independently associated with CPVL.RESULT:
CPVL developed in 19 (5.9%) infants of 1, 188+/-236 g birth weight and 28(+6)+/-2(+4) weeks gestational age. Incidence of CPVL according to birth weight and gestational age were as follows respectively <750 g 5.3%, 750-999 g 5.5%, 1, 000-1, 249 g 3.9%, 1, 250-1, 499 g 7.9% and <25weeks 8.3%, 25-26weeks 6.7%, 27-28weeks 6.5%, 29-30weeks 2.7%, 31-32weeks 11.1%. The mean day of diagnosis of CPVL was 41+/-33 days. Univriate analysis indicate that two clinical variables, prolonged ventilator duration (CPVL control, 35+/-64 days vs 17+/-26 days, P=0.0184) and severe intraventricular hemorrhage (IVH) (21% vs 2.7%, P=0.0324), were significant predictors of CPVL. The odds ratio estimate and 95% confidence limits are 1.012 and 1.003 to 1.022, respectively for prolonged ventilator duration; 2.6 and 1.044 to 6.602, respectively for severe IVH.CONCLUSIONS:
These data suggest that prolonged ventilator duration and severe IVH increase the risk for development of CPVL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Birth Weight
/
Leukomalacia, Periventricular
/
Ventilators, Mechanical
/
Logistic Models
/
Odds Ratio
/
Medical Records
/
Incidence
/
Risk Factors
/
Ultrasonography
/
Gestational Age
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
Korean
Journal:
Journal of the Korean Society of Neonatology
Year:
2003
Type:
Article
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