Experimental study on the effects of serial artificial CO2 bathing / 日本温泉気候物理医学会雑誌

ABSTRACT

Actual changes in tissue partial pressures of each gas and tissue perfusion with serial artificial CO₂ bathing were evaluated by means of medical mass spectrometry using 5 rabbits.<br>An artificial CO₂ bath was prepared by adding “BUB”-KAO, a 50g sodium hydrogencarbonate and succinic acid tablet producing fine CO₂ bubbles in water of constant temperature 20-litre tub at 36-37°C.<br>Regional tissue perfusion volume was determined on the basis of a clearance curve for Argon tissue partial pressure which was monitored by an on-line computer system with mass spectrometry.<br>Increase in subcutaneous tissue PCO₂ changed from 27% to 10%, and in PO₂ from 12% to 5% on average by serial bathing every day for 4 weeks, on the other hand tissue perfusion volume was increased in 3 out of 5 cases; from 20.85±3.56 (X±SE) m<i>l</i>/100g/min, SD=6.71, p<0.05 to 25.23±8.00 (X±SE) m<i>l</i>/100g/min, SD=6.96, p<0.05.<br>CO₂ has been shown to be locally absorbed through the skin resulting in the elevation of subcutaneous tissue CO₂ partial pessure which decreases depending on the tissue perfusion irrespective of metabolic processes. It is, therefore, assumed that the elimination of absorbed constituents by serial bathings is not caused by a decrease in the percutaneous absorption rate but an increase in washing out rate by the improved tissue perfusion.