Study on anti-ondontitis effect of extracted solution from bark of Hopea odorata Roxb

ABSTRACT

Hopea Odorata Roxb (HO) is often used by many Vietnamese people as a remedy for dental caries. However, nothing is known about which compound(s) of the material and how it (they) acts to protect the teeth. It was found in this study that the ethanol extract of Hopea odorata Roxb bark (HOE) was strongly inhibited acid production of Streptococcus mutans cells in suspension and biofilms as well. The extract also killed the organisms in acidified medium. At a concentration of 10% HOE, 90% of population was killed by 10 min and 30 min at pH 4.0 and 7.0, respectively. Killing ability of HOE was augmented when combined with hydroperoxide. In reduced pH and killing assays, the cells in biofilm appeared to be more resistant to the effect of the HOE compared to the cells in suspension. Further investigation should be needed to elucidate the anticariogenic effects of HOE