Inhibitory Effects of Na2SO4-NaHCO3 Bathing on Blood Pressure and Biochemical Profile during the Aging Process in Spontaneously Hypertensive Rats / 日本温泉気候物理医学会雑誌

ABSTRACT

To find the correlation between the inhibitory effects of hot-spring water on blood-pressure and its chemical composition, the effects of artificial spa bathing on lowering blood pressure were compared with those of hot-spring bathing on spontaneously hypertensive rats (SHR). Further, the induction of heat-shock proteins (HSP) in rat organs was quantitatively examined in order to clarify the mechanism of its action. Artificial spa (Na₂SO₄-Na₂HCO₃) bathing showed almost the same inhibitory effects on blood pressure as those of hot-spring bathing.<br>There was no significant difference in the catecholamine value in blood between both types of spa bathing, nor was there any difference from the values of the control group.<br>It was found that HSP molecules were induced in the brain, liver, and kidneys not only by hot-spring bathing but also by artificial spa bathing, with different inductive profiles from one organ to another.