The Effect of Na2SO4NaHCO3Baths. (4). Skin histamine levels following the serial bathings under subcutaneous injection of Promethazine-HCl / 日本温泉気候物理医学会雑誌

ABSTRACT

Promethazine-HCl was used to suppress histamine production in the skin by Na₂SO₄·NaHCO₃ bathing, confirming the previous data that the small amount of histamine released as a chemical mediator may have caused the warming effect, as observed in type I allergic reaction.<br>The skin histamine contents after serial bathings with Na₂SO₄·NaHCO₃ under medication of Promethazine-HCl for 3 weeks were significantly reduced compared with that of tap water (p<0.05).<br>The skin histamine produced by physical stimulation of Na₂SO₄·NaHCO₃ bathing was suppressed with H₁-blocker (Promethazine), verifying that the warming effect with Na₂SO₄·NaHCO₃ bathing was caused by histamine released as a chemical mediator, as observed in type I allergic reaction.