Experimental Studies on the Effects of Pesticide Spraying (Zinc Ethylenebis-Dithiocarbamate and N-Trichloromethylthio-Tetrahydrophthalimide) in the Vinyl Greenhouse in Rabbits / 日本農村医学会雑誌

ABSTRACT

To examine the effects of pesticides on farmers working in vinyl-covered greenhouses, subacute toxicity tests were conducted on rabbits exposed in the greenhouse a period of three months to zinc ethylenebis-dithiocarbamate (ZED) and N-trichloromethylthio-tetrahydrophthalimide (NTT), which had been sprayed once or twice a week. As a result, the authors have arrived at the following conclusions:<BR>1) Either ZED or NTT did not inhibit the growth of the rabbits during the period.<BR>2) Any significant changes attributable to the spraying of both pesticides were not detected in blood, urine and biochemical examinations.<BR>3) Pathohistological examination showed the infiltration of polymorphonuclear leukocytes and histocytes in the interalveolar tissue of the lungs of the NTT-exposed rabbits. However, in the case of the ZED-exposed group of rabbits, the infiltration was so slight that there was veritably no difference from the control group.<BR>In the brain, heart, liver, kidney, spleen, suprarenal gland, stomach and intestines, there were no abnormalities worth mentioning.<BR>4) In several cases of the NTT-exposed group, inflammation was observed in their eyes and skins, whereas nothing abnormal were observed in the ZED-exposed group.<BR>5) The concentration of ZED in air within the vinyl greenhouse at a time of spraying was 0.35mg/m3 and NTT measured 0.20mg/m3. After a lapse of one hour, either pesticide was undetectable.