Effects of organophosphorus compounds, prothiofos, cyanofenphos and chlorpyrifos on lipid metabolism in rats / 日本農村医学会雑誌

ABSTRACT

In order to observe the effects of organophosphorus compounds on lipid metabolism, 4mg of prothiofos, cyanofenphos or 1mg of chlorpyrifos were administered per os to different groups of rats, and the results were as follows;<BR>1) Serum cholinesterase activity was significantly suppressed in the experimental group administered these pesticides compared with the control group, administered salad oil only.<BR>2) The lipase activity in the liver was suppressed by administration of prothiofos and that in the kidney was also suppressed by cyanofenphos. There was a close positive correlation between the cholinesterase and lipase activity in epididymal adipose tissues of rats administered prothiofos or cyanofenphos. Furthermore, the positive correlation between the cholinesterase and lipase activity in the kidney was close on day 2 after administration.<BR>3) The acyl CoA synthetase activity in the liver of rats administered cyanofenphos was signifcantly lower than that of the control group, and there was close positive correlation between the cholinesterase and acyl CoA synthetase activity in the rats administered prothiofos.<BR>4) The serum concentration of beta-lipoprotein decreased in the group administered cyanofenphos or chlorpyrifos.<BR>5) The suppression of the lipase and acyl CoA synthetase activity was independent of the serum concentration of immunoreactive insulin.