Lipid peroxidative damage and inhalation toxicity by suspended particulate pesticide / 日本農村医学会雑誌

ABSTRACT

High concentration of airborne particles was detected in greenhouse air after suspended particulate pesticide spraying. The reduction of aerial concentration of resprirable particulate pesticide was relatively slow.<BR>To study the potential health effects of inhaled pesticide, the animals were exposed to the pesticide, methidathion particles in the inhalation exposure chamber. The exposed pesticide particles were approximately 2.16 μm mass median diameter.<BR>The animals exposed to suspended particulate pesticide had a considerable amount of particles within alveolar macropharges and alveolar epithelia. The serious lesion of alveolar epithelia and capillary endothelia of the animals occured after inhalation of methidathion particles.<BR>The vacuolar degeneration of hepatic cell was also cytosol decreased significantly after inhalation of methidathione particles.<BR>The exposure to suspended particulate methidathion induced production of thiobarbituric acid reacting substances (TBARS) in hepatic cells of the exposed animals. The induction of TBARS formation in hepatic cells was remarkable at early period of exposure.<BR>The change of serum transaminase (GOT) activities after exposure to methidathion particle was remarkable. GOT activities also markedly increased at early period of exposure.