Long-term hypolipidemic effect and safety of pravastatin compared with cessation of therapy in patients with hyperlipidemia
Korean Circulation Journal
;
: 142-148, 1993.
Article
in Korean
| WPRIM
| ID: wpr-37364
ABSTRACT
BACKGROUND:
Hyperlipidemia is the one of the major risk factors causing the atherosclerosis of coronary arteries. Treatment of hyperlipidemia with drugs has been confirmed the effcts of therapy showing a decreased incidence of coronary artery disease. Pravastation is one of the new HMG-CoA reductase inhibitors and we studied the long-term hypolipidemic effects and safety of pravastatin in patients with hyperlipidemia and lipid profile after cessation of pravastatin therapy.METHODS:
We studied 27 patients(6 males and 21 females, range of age 36~67 years) for 14.7 months whose plasma levels of total cholesterol were higher than 250mg% after one month period of diet therapy. Pravastatin was administered 10mg/day and measured lipid profile at 4 weeks interval, and at 2~3 months after cessation of therapy.RESULTS:
1) Pravastatin significantly reduced the plasma total cholesterol, LDL-cholesterol and triglyceride, but HDL-cholesterol was increased significantly after 12 months pravastatin therapy(p<0.05). 2) Two to three months after the cessation of pravastatin therapy, plasma total cholesterol, LDL-cholesterol and triglyceride were significantly increased(p<0.05), but no significant difference was observed for HDL-cholesterol. 3) The clinical and laboratory examinations before and after pravastatin treatment showed no particular abnormal findings.CONCLUSION:
These results suggested that long-term pravastatin therapy in patients with hyperlipidemia seems to be very effective and safe. But hyperlipidemia developed again two to three months after the cessation of pravastatin therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Triglycerides
/
Coronary Artery Disease
/
Cholesterol
/
Incidence
/
Risk Factors
/
Pravastatin
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Coronary Vessels
/
Diet Therapy
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1993
Type:
Article
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