Effects of habitual exercise and diet restriction on the hepatic fat accumulation in Zucker fatty rats / 体力科学
Japanese Journal of Physical Fitness and Sports Medicine
;
: 223-229, 2014.
Article
in English
| WPRIM
| ID: wpr-375220
ABSTRACT
We investigated the effects of habitual exercise and diet restriction on the hepatic fat accumulation in Zucker fatty rats. Male 6-week-old Zucker fatty rats were divided into obese (Ob), diet restriction (DR), and diet restriction + exercise (DR + Ex) groups. Male Zucker lean rats (L) were used as a control group. The rats in the L and Ob groups were maintained on ad libitum diets. The rats in the DR and DR + Ex groups were fed a 30% restricted diet. The rats in the DR + Ex group exercised voluntarily on a wheel ergometer. After 6 weeks of intervention, the serum free fatty acid and leptin levels in the Ob group were significantly higher than those in the L group. In the Ob group, the hepatic triglyceride content was higher than that in the L group and hepatocyte fat infiltration was observed on haematoxylin and eosin staining. These changes were suppressed by DR + Ex, but not by the DR intervention. These results suggest that habitual exercise inhibits fat accumulation in the liver of Zucker fatty rats.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Japanese Journal of Physical Fitness and Sports Medicine
Year:
2014
Type:
Article
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