Radiation Absorbed Dose Measurement after I-131 Metaiodobenzylguanidine Treatment in a patient with Pheochromycytoma / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 422-429, 1999.
Article
in Korean
| WPRIM
| ID: wpr-37533
ABSTRACT
PURPOSE:
The measurement of radiation absorbed dose is useful to predict the response after I-131 labeled metaiodobenzylguanidine (MIBG) therapy and determine therapy dose in patients with unresectable or malignant pheochromocytoma. We estimated the absorbed dose in tumor tissue after high dose I-131 MIBG in a patient with pheochromocytoma using a gamma camera and Medical Internal Radiation Dose (MIRD) formula. MATERIALS ANDMETHODS:
A 64-year old female patient with pheochromocytoma who had multiple metastases of mediastinum, right kidney and periaortic lymph nodes, received 74 GBq (200 mCi) of I-131 MIBG. We obtained anterior and posterior images at 0.5, 16, 24, 64 and 145 hours after treatment. Two standard sources of 37 and 74 MBq of I-131 were imaged simultaneously. Cummulated I-131 MIBG uptake in tumor tissue was calculated after the correction of background activity, attenuation, system sensitivity and count loss at a high count rate.RESULTS:
The calculated absorbed radiation dose was 32-63 Gy/ 74 GBq, which was lower than the known dose for tumor remission (150-200 Gy). Follow-up studies at 1 month showed minimally reduced tumor size on computed tomography, and mildly reduced I-131 MIBG uptake.CONCLUSION:
We estimated radiation absorbed dose after therapeutic I-131 MIBG using a gamma camera and MIRD formula, which can be peformed in a clinical nuclear medicine laboratory. Our RESULTS suggest that the measurement of radiation absorbed dose in I-131 MIBG therapy is feasible as a routine clinical practice that can guide further treatment plan. The accuracy of dose measurement and correlation with clinical outcome should be evaluated further.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pheochromocytoma
/
Gamma Cameras
/
Follow-Up Studies
/
3-Iodobenzylguanidine
/
Kidney
/
Lymph Nodes
/
Mediastinum
/
Neoplasm Metastasis
/
Nuclear Medicine
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Nuclear Medicine
Year:
1999
Type:
Article
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