Risk Factors and Subjective Symptoms of Drug-Induced Thrombocytopenia / 医薬品情報学
Japanese Journal of Drug Informatics
;
: 70-80, 2014.
Article
in English
| WPRIM
| ID: wpr-375927
ABSTRACT
<b>Objective:
</b>The present study investigated risk factors and subjective symptoms associated with drug-induced thrombocytopenia.<br><b>Methods:
</b>We selected 361 patients with drug-induced thrombocytopenia from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database of over 65,000 case reports of adverse drug reactions and assigned these patients to a case group. We also randomly selected 794 cases of adverse drug reactions not associated with thrombocytopenia as a control group.<br><b>Results:
</b>Data were compared between the case and control groups, and results were analyzed using logistic regression analysis. We identified type of infection (non-viral) and renal failure as risk factors for drug-induced thrombocytopenia. In addition, administration of carbamazepine, methotrexate, interferon alpha, ticlopidine or valproic acid significantly increased the risk of drug-induced thrombocytopenia. Significant associations were also found between drug-induced thrombocytopenia and purpura, fever, and mucosal bleeding.<br><b>Conclusion:
</b>These findings provide helpful information for early detection and prevention of thrombocytopenia as a serious adverse drug reaction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Language:
English
Journal:
Japanese Journal of Drug Informatics
Year:
2014
Type:
Article
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