Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus
Immune Network
;
: 115-124, 2002.
Article
in Korean
| WPRIM
| ID: wpr-37604
ABSTRACT
BACKGROUND:
The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined.METHODS:
The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines.RESULTS:
The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines.CONCLUSION:
These results suggest that the exo- secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chemotaxis
/
Cytokines
/
Cell Line, Tumor
/
Tumor Burden
/
Amino Acids
/
Leukocytes
/
Mice, Inbred ICR
/
Monosaccharides
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Immune Network
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS