A Drug Utilization Study on Off-Label Uses / 薬剤疫学

ABSTRACT

Objective: Heparin lock flush solution is diluctes and divided into vials before its use while it is used in quantity in Japan. Then, we carried out the research on use of heparin lock flush solution.<BR>Methods: We executed the nationwide questionnaire investigation concerning making heparin lock flush solution.<BR>Results: The recovery of the nationwide questionnaire investigation was as high as 78% (64/82) indicating general concern for the problem.<BR>Heparin lock flush solution was made in 97% (246/253) of wards. 69% (174/253) of wards had a standard for preparation. Therebon, it is thought that the standardization of heparin lock flush solution is possible. The use concentration employed most frequently for the peripheral intravenous injection was 10 units/ml and that for the central vein injection was 100/ml units. In many wards the amount used at 1 time for the peripheral intravenous injection was 5 ml or 10 ml and that for the central vein injection, was 5 ml, 10 ml, or 20 ml.<BR>84% of nurses requested marketing of heparin lock flush solution.<BR>Conclusion: We investigated the use realities and the problem of heparin lock flush solution from a past report etc. Heparin lock flush solution is listed to the pharmacopeia in the United States and Britain. Heparin lock flush solution should be supplied as the goods on the market immediately even if it is seen from the profit, the safety, the medical economy.