Efficacy and Safety of Denopamine in Patients with Chronic Heart Failure / 薬剤疫学
Japanese Journal of Pharmacoepidemiology
;
: 13-20, 2002.
Article
in Japanese
| WPRIM
| ID: wpr-376075
ABSTRACT
Objective:
To investigate the safety and effects of long-term administration of denopamine, β-1 stimulant, on the activities of daily living in heart failure patients.<BR>Design:
Case-series.<BR>Methods:
One hundred forty patients with mild to moderate chronic heart failure were administered denopamine at dose of 5 to 10 mg three times daily for 24 weeks. Concomitant circulatory system drugs such as digitalis, diuretics, vasodilator drugs, etc., were used without changing the administration method and dose. However, the use of a concomitant β-blocker was prohibited.<BR>Results:
Following administration of denopamine, the NYHA cardiac function classification improved by one degree or more in 50 patients (35.7%). The body weight decreased significantly from 54.9± 10.2kg (mean±SD) before administration to 54.0±10.2kg after administration (P<0.05), and the cardiothoracic ratio also decreased from 58.0±7.3% to 56.6±7.2% (P<0.001). No significant changes were observed in the heart rate, systolic blood pressure, or diastolic blood pressure. The activities of daily living improved by one level or more for 49 patients (51.6%). There were 36 withdrawal or dropout cases (patients' own convenience 12 cases ; complications/accidental symptoms 7 cases) during the investigation period. Four patients (2.9%) exhibited adverse reactions.<BR>Conclusion:
Denopamine seemed to improve the quality of life, which is one of the therapeutic purposes for patients with chronic cardiac failure. A large-scale study including investigation of the long-term prognosis for such patients needs to be performed.
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Index:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Japanese Journal of Pharmacoepidemiology
Year:
2002
Type:
Article
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