miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
Experimental & Molecular Medicine
;
: e123-2014.
Article
in English
| WPRIM
| ID: wpr-37644
ABSTRACT
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated. In this study, we demonstrate the potential role of miR-27 in the regulation of mitochondrial dynamics. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. Expression of miR-27 results in the elongation of mitochondria as well as an increased mitochondrial membrane potential and mitochondrial ATP level. Our results suggest that miR-27 is a novel regulator affecting morphological mitochondrial changes by targeting MFF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Biosynthesis
/
RNA, Messenger
/
Cell Line
/
Gene Expression Regulation
/
3' Untranslated Regions
/
Mitochondrial Proteins
/
MicroRNAs
/
Membrane Potential, Mitochondrial
/
Mitochondrial Dynamics
/
Membrane Proteins
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2014
Type:
Article
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