Suppression of Proliferation of Prostate Cancer Cells and Benign Prostatic Hyperplasia by Porcine Placenta Extracts / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 219-224, 2008.
Article
in Japanese
| WPRIM
| ID: wpr-376462
ABSTRACT
<i>Objective</i> Anti-androgenic action of porcine placenta extracts were investigated.<br> <i>Methods</i> To determine if porcine placenta extracts can inhibit androgen-stimulated growth of LNCaP cells, a dose response assay was performed. LNCaP cells were treated with varying concentrations of porcine placenta extracts with or without dihydrotestosterone.<br> A castrated rat was used to study influence of an exogenous androgen.<br> <i>Results</i> Porcine placenta extracts-treated cells showed a statically significant decrease in cell number, indicating decreased cell growth.<br> The secretion of PSA(prostate specific antigen) was determined by ELISA. It was also inhibited in the presence of porcine placenta extracts and dihydrotestosterone.<br> Immunoblotting detected decreases in androgen receptor protein after treatment with the porcine placenta extracts.<br> In vivo studies in a castrated rat showed that enlargement of the prostate by testosterone was inhibited by porcine placenta extracts.<br> <i>Conclution</i> These results suggest that porcine placenta extracts contain a substance with anti-androgenic actions.<br>
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Index:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Japanese Journal of Complementary and Alternative Medicine
Year:
2008
Type:
Article
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