Effect of the Reduced Coenzyme Q10 and Exercise Training on the Senescence and Exercise Capacity, Oxidative Stress Regulation System in SAMP1 Mice / 日本補完代替医療学会誌

ABSTRACT

<b>Objective</b> We studied the effect of long-term the reduced form of coenzyme Q10 (H₂CoQ10 QH) consumption and exercise training (EX) with SAMP1 mice on senescence, exercise capacity, and an oxidative stress regulation system.<br> <b>Methods</b> The subjects of this study were 50 SAMP1 mice for accelerated senescence, sorted at random into four groups one which consumed QH, one which consumed QH and performed EX, one which performed EX, and a control group. The experiment started when the mice were 8 weeks old and the consumption of QH continued for 12 months (12M). The measurement for the oxidative stress regulation system was performed at the start of this study and 12M later. Running time for exercise capacity, senescence grading scores, and body weight were each measured at the start of the study, 6 months (6M) and 12M later. For the oxidative stress regulation system, we used reactive oxygen and free radical analysis equipment, with which we measured plasma oxidative stresses (d-ROM test) and plasma anti-oxidant potential (BAP test), and calculated the ratio of d-ROM to BAP.<br> <b>Result</b> A combination of QH consumption and EX showed, at a later stage, an inhibiting effect on the increase in senescence grading scores and on the decrease in running time. For the oxidative stress regulation system, the combination showed a decrease in latent anti-oxidant potential caused by the rise of plasma oxidative stresses.<br> <b>Conclusion</b> Results of this study suggest that a combination of QH consumption and EX is effective in delaying aging, inhibiting the decline of exercise capacity, and decrease in latent anti-oxidant potential.<br>