Marked lactate dehydrogenase elevation and tachypnea due to lactic acidosis in a patient with terminal stage prostate cancer: the first report in Japan
Palliative Care Research
;
: 539-542, 2015.
Article
in Japanese
| WPRIM
| ID: wpr-377111
ABSTRACT
Introduction:
To our knowledge, there is only one report of lactic acidosis in a patient with prostate cancer and no such report in Japan. We describe a patient with terminal stage prostate cancer who showed marked elevation in lactate dehydrogenase (LDH) levels and lactic acidosis. Case Report The patient was a 66-year-old man diagnosed with prostate cancer and bone and liver metastases. At the time of diagnosis, he was being treated with the best supportive care after chemotherapy and hormone therapy for prostate cancer. He was admitted to the hospital for nausea and loss of appetite. Laboratory tests showed elevated LDH levels (11,894 IU/L; LDH4, 23%; LDH5, 32%); pH, 7.402; pCO2, 13.2 mmHg; HCO3−, 8.0 mmol/L; and lactate level, 10.0 mmol/L. On the basis of the results, the patient was diagnosed with lactic acidosis. He showed tachypnea the day before his death.Conclusion:
Elevation in LDH levels, and especially of LDH5, indicates acceleration of anaerobic glycolysis from tumor cells, leading to the accumulation of lactate. The patient’s tachypnea was possibly caused by lactic acidosis.
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Index:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Palliative Care Research
Year:
2015
Type:
Article
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