The BMPs expression and histomorphometric study of beta-TCP /rhBMP-2 Grafting on the rabbit cranial bone defects
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 49-58, 2008.
Article
in English
| WPRIM
| ID: wpr-37716
ABSTRACT
OBJECTIVE:
The Purpose of the study was to investigate the bone morphogenic protein expression of rhBMP-2(recombinant human bone morphogenic protein-2) as singnaling molecule and beta-TCP(Tricalcium phosphate) as a bone substitute and carrier medium of rhBMP-2. MATERIALS ANDMETHODS:
16 rabbits divided into 2 group of each 8 rabbit. Two standardized bone defect, round bilateral defect was made in the cranium of the 8 rabbit of first group, and was grafted with 150~500micrometer diameter beta-TCP 0.25g in one side, which was soaked with rhBMP-2, and autogenous bone was grafted on another side as a positive control. Second group of 8 rabbit, only beta-TCP was grafted with same size and same manner. After 2, 4, 8, and 12 weeks, specimen was taken for microscopic immunohiostochemical and histomorphometric analysis.RESULT:
Grafting beta-TCP with rhBMP show the early formation of the bone regenerative factor (BMP-4) and more quantity of new bone formation than only use of beta-TCP (8,12 week), even show less new bone formation than autogenous bone.CONCLUSION:
The experimental study result that beta-TCP graft combination with rhBMP-2 as a delivery system is an effective with osteoinductive capacity and biodegradable properties, so that provide clinical availibility of composite use in reconstruction of bony defect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Skull
/
Calcium Phosphates
/
Immunohistochemistry
/
Bone Substitutes
/
Transplants
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2008
Type:
Article
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