Delayed Neuro-Toxicity of Organophosphorous Agents As Demonstrated by Use of Hens / 日本農村医学会雑誌

ABSTRACT

To demonstrate delayed neuro-toxicity of organophosphate, we administered 13 types of organophosphorous pesticide to hens. Initially, a screening test was performed with nine varieties of the chemical product. Later, four types were given to the fowls. Those hens dosed with S-Seven and Surecide developed ataxia and other neurophatic symptoms in the lower limbs.<BR>After 50 days of observation, all the hens were killed and anatomized. Phathohistological examination revealed various changes in the hens that developed neuropathic symptoms atrophy, diminution and disappearance of nerve cells in the anterior horn of the spinal cord ; edematous changes in the myelin; swelling of the neuroglia ; atrophy and vaculolar degeneration of liver cells; and necrobiosis of <I>nepaticlobures</I>.<BR>It was found that these changes are closely related with the development of ataxia and doses of the chemical.<BR>It was also found that the pathotistological changes occurred to a less extent in those hens which did not develop toxicoses.