Pre-emptive Effect of Methylprednisolone on the Mechanical Allodynia Development after Peripheral Nerve Injuries in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: S17-S21, 2004.
Article
in English
| WPRIM
| ID: wpr-37845
ABSTRACT
BACKGROUND:
Glucocorticoids have anti-inflammatory effects and have been used to treat many types of nerve injury- associated chronic pain conditions. A randomized double-blind study was performed to determine if methylprednisolone could prevent the development of neuropathic pain after a peripheral nerve injury in rats.METHODS:
Two groups of rats, one group (n = 50) injected intraperitoneally with methylprednisolone (100 mg/kg/day, for 7 days starting from 3 days prior to the nerve injury) and the other (n = 58) treated with saline with same manner, were compared in terms of the incidence and intensity of allodynia after a superior caudal trunk transection at the level between the 3rd and 4th sacral spinal nerves. The tail-flick responses to normally innocuous mechanical and thermal stimuli applied to the tail were observed as the behavioral signs of neuropathic pain.RESULTS:
The proportions of rats exhibiting tail-flick responses to the mechanical (but not thermal) stimuli 7, 14 and 21 days after the nerve injury were significantly smaller in the methylprednisolone-treated group (2, 3 and 4 of 50 rats, respectively) than in the saline-treated, control group (11, 14 and 15 of 58 rats, respectively) (P = 0.009). However, the pain intensity was similar in mechanical allodynia developed rats of the two groups (P > 0.05), which was estimated based on the frequency and latency of the tail-flick responses after applying mechanical and thermal stimuli, respectively.CONCLUSIONS:
These results suggest that a pre-emptive treatment with high methylprednisolone doses may be used to prevent the development of mechanical allodynia following peripheral nerve injuries.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peripheral Nerves
/
Spinal Nerves
/
Methylprednisolone
/
Double-Blind Method
/
Incidence
/
Axotomy
/
Chronic Pain
/
Peripheral Nerve Injuries
/
Glucocorticoids
/
Hyperalgesia
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2004
Type:
Article
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