<b>Shinbuto-Boiogito Prevents the Progression of Chronic Kidney </b><b>Disease</b> / 日本東洋医学雑誌

ABSTRACT

<p>Nephrosclerosis is a chronic kidney disease that gradually aggravates. Many elderly patients eventually require dialysis due to nephrosclerosis, which is the third-greatest cause of dialysis initiation. Past studies have shown that Chinese herbal medicines such as <i>shinbuto </i>may be effective for treatment. We evaluated the effect of concomitant <i>shinbuto </i>and <i>boiogito </i>extract administration to slow the progression of renal failure in patients with chronic kidney disease suspected to have nephrosclerosis. Our study included 20 patients with nephrosclerosis (12 male ; 8 female ; mean age, 76.2 years) treated at the Nephrology Department of Kagawaken Saiseikai Hospital on an outpatient basis. <i>Shinbuto </i>extract granules 5 g and <i>boiogito </i>extract granules 5 g were divided into two doses and given to the patients before breakfast and dinner. Laboratory tests were performed at baseline, 3 months, and 6 months. Serum creatinine levels decreased from 2.04 mg/dL at baseline to 1.72 mg/dL at 3 months and 1.59 mg/dL at 6 months, while eGFR increased from 26.8 mL/min at baseline to 32.2 mL/min at 3 months and 35.3 mL/min at 6 months (p < 0.01). Other laboratory tests showed no change. <i>Shinbuto-boiogito </i>may improve the renal function in patients with chronic kidney disease suspected with nephrosclerosis based on these data.</p>