Safety Evaluation of Methoxyflavones Mixture (Ⅱ) from Kempferia parviflora:28-day Repeated Dose Oral Toxicity Test / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 33-37, 2017.
Article
in Japanese
| WPRIM
| ID: wpr-378872
ABSTRACT
Kaempferia parviflora rhizome is used folk medicines for treatment of various symptoms in Thailand since anticent times.Several types of methoxyflavones has been identified in this plant and their physiological functions have been reported.We determined that six kinds of methoxyflavones (5,7,3',4'-tetramethoxyflavone, 3,5,7,3',4'-pentamethoxyflavone, 5,7-dimethoxyflavone, 5,7,4'-trimethoxyflavone, 3,5,7-trimethoxyflavone, 3,5,7,4'-tetramethoxyflavone) were included in the 80% ethanol extract of K. parviflora rhizome.The safety of six methoxyflavones mixture was evaluated with 28-day repeated oral dose toxicity test in mice.These results indicated no significant toxicity on body weight, blood analyses, organ weight, blood biochemical analyses.
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Index:
WPRIM (Western Pacific)
Language:
Japanese
Journal:
Japanese Journal of Complementary and Alternative Medicine
Year:
2017
Type:
Article
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