Effects of Cyclosporine on the Intrarenal Renin-Angiotensin System / 대한신장학회잡지
Korean Journal of Nephrology
;
: 679-685, 1998.
Article
in Korean
| WPRIM
| ID: wpr-37923
ABSTRACT
The present study was aimed at investigating the effect of cyclosporine A (CsA) on the renal renin-angiotensin systems. In rats chronically treated with CsA, the intrarenal expression of various genes of the renin-angiotensin system was assessed by Northern blot analysis. Along with the increases in plasma and renal renin activities, chronic CsA-treatment differentially affected the renal expression of renin-angiotensin system. The treatment with CsA for one week did not significantly alter the expression of either type 1 angiotensin II receptor (AT1A) or angiotensinogen gene, but increased the renin mRNA level. The three-week-treatment caused increases in the expression not only of renin but also of AT1A and angiotensinogen genes. Supplementation with L-arginine kept the expression of renin mRNA normal in the one-week-treated, but failed to prevent the alterations of the gene expression in the three-week-treated. Feedback control among components of the renin-angiotensin system also influences angiotesinogen. In the liver, the expression of angiotensinogen mRNA was decreased by the CsA-treatment for either one- or three-weeks. In conclusion, chronic CsA-treatment is associated with a differential expression of various genes for the renin-angiotensin system. L-Arginine may be effective in maintaining the normality of renin-angiotensin system only during early period after beginning the use of CsA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arginine
/
Plasma
/
Renin-Angiotensin System
/
RNA, Messenger
/
Receptors, Angiotensin
/
Gene Expression
/
Angiotensinogen
/
Blotting, Northern
/
Renin
/
Cyclosporine
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
1998
Type:
Article
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