Expression of Fas, FasL system and C-erbB-2 in breast cancer and its clinical significance / 肿瘤研究与临床

ABSTRACT

Objective To explore the correlations of expression of Fas, FasL and C-erbB-2, its clinical significance and the correlation prognosis. Methods To protect the expression of mFas, mFasL and C-erbB-2 by immunohistochemistry SP method. To protect the sFas content by ELISA method. Results The expression of Fas showed lowest levels in breast carcinoma, showed lower levels in fibro-adenoma of breast and breast atypical hyperplasia, and showed highest levels in normal controls. The expression of FasL showed adversely, sFas showed highest levels in breast carcinoma, then in breast atypical hyperplasia, and showed lowest levels in normal control group. Fas and C-erbB-2 obviously presented negative correlation. Conclusion The expression of mFas showed inhibition in breast carcinoma, adversely the expression of mFasL showed enhancement, hint abnormality expression of mFas, mFasL may relevant tomammary glands cancer of occurrence and development. It can be used for estimating prognosis, but need a further research.